Pregnant and breastfeeding women should not take modafinil. It is excreted into breast milk and may cause serious harm to the baby.
Use an effective method of birth control while taking this medicine and for 1 month afterward. Ask your doctor for details.
A recent study of the pregnancy registry found that babies born to mothers who took Provigil or Nuvigil in their first trimester had a higher rate of malformations than those born to mothers who did not take these drugs.
Dosage
Modafinil 200mg Online is a CNS stimulant used to treat the sleep disorders narcolepsy, obstructive sleep apnea/hypopnea syndrome, and shift work disorder. It works by changing certain chemicals in the brain that control your sleep/wake cycle.
Modafinil is not a substitute for sleep, and it should not be taken by people who do not have a sleep disorder. It may cause serious or life-threatening skin reactions, including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). This medication is not approved for use in children younger than 17 years.
Rare cases of severe or life-threatening rash, including SJS and TEN, have been reported in adults and children taking modafinil in worldwide postmarketing experience. These rashes appear to be related to the development of hypersensitivity to this drug, and they have been associated with symptoms such as fever, swelling, redness, and blisters. In some cases, TEN has been associated with liver failure and death.
This medicine interacts with several other drugs. Serum concentrations decrease significantly when administered with drugs that induce CYP3A4 (e.g., rifampin, phenytoin). Its effectiveness may be reduced by certain antidepressants (e.g., TCAs such as clomipramine/desipramine, SSRIs such as fluoxetine, fluvoxamine), and cyclosporine, among others.
This medication is excreted into breast milk. Women should not breastfeed while taking this drug, and if they do, they should use an alternate method of birth control.
Side effects
Modafinil may affect your ability to think clearly or concentrate. This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can increase these effects. Avoid alcoholic beverages. Modvigil 200 mg can interact with many drugs, including narcotic pain medications and antidepressants.
This medication should not be used during pregnancy. Tell your doctor if you are breastfeeding or plan to nurse.
A severe allergic reaction called angioedema has occurred in some people taking this medication. This reaction can be life-threatening. Signs and symptoms of angioedema include swelling of the face, eyes, lips, tongue, or throat; difficulty swallowing or breathing; and hoarseness. These reactions are rare. If you have these symptoms, stop taking this medication and contact your doctor immediately.
Modafinil may slow the removal of other medications from your body, which can cause a dangerous effect when taken with certain medicines. This includes an antibiotic called clarithromycin and other drugs to treat hepatitis C, such as ombitasvir/paritaprevir/ritonavir or a combination product containing these medications.
Also, this medication can decrease the effectiveness of hormonal birth control pills, injections, patches, or vaginal rings. Therefore, you should use another form of birth control while taking this medication and for 1 month afterward.
Precautions
This medication may cause dizziness. Drinking alcohol can worsen these effects. This medicine may also interact with certain foods. Check the label for a complete list of interactions.
Modafinil may make birth control pills less effective. Use an alternative form of birth control while taking this medicine and for 1 month after stopping it. This medicine can pass into breast milk and could harm a nursing baby.
Rare cases of serious skin reactions, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), have been reported in patients taking modafinil. These reactions can be fatal. Report any signs or symptoms of these rare but serious side effects to your doctor right away.
Modafinil can increase levels of certain drugs that are eliminated by the liver’s CYP3A4 enzyme, including cimetidine, verapamil, and gemfibrozil. It may also decrease levels of CYP3A4 substrates (eg, carbamazepine, phenobarbital) or drugs eliminated by the kidney’s CYP2C19 enzyme (eg, warfarin).
These effects can lead to increased blood levels of these drugs and serious or life-threatening side effects. Monitor these levels closely, especially if you are elderly or have severe hepatic impairment.
Overdose
Modafinil is excreted into breast milk in small amounts and has been associated with adverse reactions of the psychiatric and nervous systems in infants exposed to breastfeeding. These included Tourette’s syndrome, mania, hostility, increased cataplexy, and hypnagogic hallucinations.
Dysmenorrhea has also been reported in a controlled clinical study. The excretion of R-modafinil into milk has not been adequately measured in the published case reports, and no data are available on S-modafinil excretion in human breast milk.
Until more information is available, modafinil should be used with caution by women who are nursing and women who plan to become pregnant. It is recommended that an alternative method of contraception be used in addition to oral contraceptives in these women, as modafinil may reduce their efficacy.
Patients with a history of psychosis or mania should be closely monitored, as well as those with a prior history of cardiotoxicity related to the use of other stimulants, and be advised that serious skin reactions (such as Stevens-Johnson syndrome) have been associated with the use of modafinil. Patients with severe hepatic impairment should receive reduced doses.
Read it carefully and ask your doctor or pharmacist to explain any part you do not understand. Take this medicine by mouth with or without food as directed by your doctor, usually once a day in the morning. For narcolepsy or obstructive sleep apnea, your dose may be divided into a morning and noon dose.
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