Wegovy is an injectable prescription medication used for weight management. It contains the active ingredient semaglutide, which is a GLP-1 (glucagon-like peptide-1) receptor agonist. This medication is designed to help individuals with obesity or overweight conditions achieve weight loss when combined with a reduced-calorie diet and increased physical activity. The approval of Wegovy Injections in Dubai by the U.S. Food and Drug Administration (FDA) marks a significant milestone in obesity treatment.
FDA Approval of Wegovy
Wegovy was approved by the FDA in June 2021 as a treatment for chronic weight management in adults who meet specific criteria. This approval followed clinical trials that demonstrated the drug’s efficacy in helping patients lose weight and maintain long-term weight loss. The FDA approved Wegovy based on its success in reducing body weight in patients with obesity or those who are overweight and have at least one weight-related health condition, such as hypertension, type 2 diabetes, or high cholesterol.
The medication is approved for:
- Adults with a body mass index (BMI) of 30 or higher (obesity).
- Adults with a BMI of 27 or higher (overweight) and at least one weight-related comorbidity (such as heart disease, type 2 diabetes, or hypertension).

How Wegovy Works
Wegovy mimics the effects of the hormone GLP-1, which is naturally produced in the intestines. GLP-1 plays a key role in regulating appetite and food intake by signaling to the brain when to stop eating. Wegovy works by:
- Reducing Appetite: It helps control hunger by affecting the brain’s hunger signals.
- Slowing Gastric Emptying: It slows the emptying of food from the stomach, leading to prolonged feelings of fullness after eating.
- Regulating Blood Sugar: It also has effects on glucose metabolism, which can be beneficial for individuals with type 2 diabetes.
Clinical Trials and Evidence Supporting Wegovy’s Approval
The FDA’s approval of Wegovy was based on the results from clinical trials that showed significant weight loss among participants who used the drug. In these trials, participants who received Wegovy, in combination with diet and exercise, experienced an average weight loss of around 15% of their total body weight after 68 weeks of treatment. This is a significant improvement compared to a placebo group, which only experienced modest weight loss.
Additionally, Wegovy was shown to help improve various health markers associated with obesity, such as:
- Blood pressure
- Cholesterol levels
- Blood sugar levels
- Risk factors for heart disease
Dosage and Administration
Wegovy is administered through a subcutaneous injection once a week. The injection is typically given in the abdomen, thigh, or upper arm.
- Initial Dosage: The starting dose is typically 0.25 mg once a week.
- Gradual Increase: Over a period of 4 weeks, the dosage is gradually increased to 2.4 mg once a week. This helps reduce side effects and allows the body to adjust to the medication.
- Long-Term Use: Wegovy is intended for long-term use in conjunction with a reduced-calorie diet and increased physical activity. It should be discontinued if weight loss goals are not met after 16 weeks of treatment.
Potential Side Effects
Like all medications, Wegovy may cause side effects. Some common side effects include:
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Headache
- Fatigue
In some cases, more serious side effects may occur, such as:
- Pancreatitis (inflammation of the pancreas)
- Kidney problems
- Thyroid tumors (a risk based on animal studies)
- Hypoglycemia (low blood sugar), especially in people with type 2 diabetes who are also taking insulin or sulfonylureas
Patients considering Wegovy should discuss potential side effects with their healthcare provider to determine whether it is an appropriate treatment for them.
Conclusion
Yes, Wegovy injections are FDA-approved for weight management in adults with obesity or overweight conditions. It is a highly effective medication that can help individuals lose weight, improve overall health, and reduce the risk of complications related to obesity. However, like all medications, Wegovy should be used under the supervision of a healthcare provider, and it should be part of a comprehensive weight management program that includes a balanced diet and regular physical activity.
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